Aging of the innate immune system

HIV infection and aging of the innate immune system.

The increased life expectancy of HIV-infected individuals due to improved treatment has revealed an unexpected increase in non-AIDS comorbidities that are typically associated with older age including cardiovascular disease, dementia and frailty. The majority of these diseases arise as the result of dysregulated systemic inflammation, and both the aged and HIV-infected individuals exhibit eleva...

The innate immune system

The innate immune system ; is an important subsystem of the overall immune response system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system, the system does not confer long-lasting or protective immunity to the host. Innate imm...

Modelling the Innate Immune System

The Human Immune System (HIS) is a complex network composed of specialized cells, tissues, and organs that is responsible for protecting the organism against diseases caused by distinct pathogenic agents, such as viruses, bacteria and other parasites. The first line of defence against pathogenic agents consists of physical barriers of skin and the mucous membranes. If the pathogenic agents brea...

Signaling Organelles of the Innate Immune System

There are at least five families of microbe-detection receptors that function to detect and eradicate potentially infectious microorganisms that enter multicellular eukaryotes. While a multitude of proteins regulating innate immune signal transduction have already been defined, continuous genetic screening for regulators of innate immunity may not yield as significant insight into the operation...

The Immune System, Hiv, & Aging